400 million years ago – Falls of the Ohio (Devonian fossil beds)
1778 – Louisville founded – Main Street Association
1791 – Locust Grove (Historic)
1816 – Farmington Historic Home
1837 – Riverside, the Farnsley-Moremen Landing
1850 – (c.) – Thomas Edison House
1852 – Historic home (Beech Grove) that is foundation of the Portland Museum
1852 – US Marine Hospital1855– Nunnlea
1855– (c.) – Whitehall Historic Home
1858 – American Printing House for the Blind
1860 – Jefferson County Courthouse (now Metro Hall)
1860 – Louisville Water Company Water Tower and Pumping Station
1868 – Brennan Historic House (now headquarters for Preservation Louisville, Inc.)
1869 – Culbertson Mansion
1870 – Little Loomhouse
1881 – Life Saving Station #10 (with Belle of Louisville); current vessel constructed in 1929
1891 – Leora Brown School
1894 – Howard Steamboat Museum
1895 – Conrad-Caldwell House Museum
1904 – Carnegie Center for Art and History (Carnegie Library)
1910 – Filson Historical Society (Ferguson Mansion)